Highly soluble multicomponent inclusion complexes containing a base type drug, an acid and a cyclodextrin
AssigneeChiesi Farmaceutici S.p.A.
InventorsPaolo Chiesi, Paolo Ventura, Massimo Pasini, Josef Szejtli, Maria Vikmon, Enrico Redenti
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Abstract
A multicomponent inclusion complex of a basic drug, an acid and a cyclodextrin has enhanced water-solubility.
Claims19
A multicomponent inclusion complex, comprising a basic drug, an acid and a cyclodextrin, obtained by combining said basic drug in unsalified form, said acid and said cyclodextrin.
A method for preparing a multicomponent inclusion complex, comprising the steps of:
- (a) suspending a basic drug in unsalified form, an acid and a cyclodextrin in water to form a suspension;
- (b) homogenizing said suspension to obtain a clear or opalescent solution;
- (c) optionally filtering said solution to obtain a clear solution;
- and
- (d) dehydrating the resulting solution.
A method of increasing the water-solubility of acyclodextrin, comprising mixing an acid selected from the group consisting of organic acids and halogenhydric acids, with said cyclodextrin.
Dependencies are inferred from the claim text.