Tablets or biologically acceptable implants for long-term antiinflammatory drug release
AssigneeBaylor University
InventorA. George Pinkus
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Abstract
The present invention involves an aspirin/polyglycolide complex, its preparation and use. The complex provides a stable aspirin source, slowly releasing aspirin by dissociation or during polyglycolide degradation in vivo.
Claims7
A composition of matter useful for the slow release of a biologically active carboxyl-containing compound, the composition being formed by preparing a molten solution of a polyglycolide and a carboxyl-containing biologically active compound;
- and cooling said molten solution to form a complex of the polyglycolide and carboxyl-containing compound having a compound:monomeric unit ratio of at least about 1:1.
A complex formed by preparing a molten mixture of a polyglycolide and a carboxylic acid selected from the group consisting of acetylsalicylic acid, (S)-(+)4-isobutyl-.alpha.-methylphenylacetic acid, phenylacetic acid, phenoxyacetic acid, benzoic acid and salicylic acid;
- the complex having a carboxylic acid:monomer unit ratio of at least about 1:1.
A complex between a polyglycolide and a carboxyl-containing biologically active compound, in a ratio of carboxylate compound to momomeric polyglycolide unit of from about 1:10 to about 10:1.
An aspirin polyglycolide complex produced by preparing a molten mixture of aspirin and polyglycolide and solidifying said mixture.
A composition of matter comprising an aspirin-polyglycolide complex having an aspirin:monomeric ratio of at least about 1:1.
An aspirin polyglycolide complex having an aspirin:monomer ratio of at least about 1:1 and formed by melting a mixture of polyglycolide and aspirin.
Dependencies are inferred from the claim text.