Pharmaceutical compositions for piperidinalkanol compounds
AssigneeHoechst Marion Roussel, Inc.
InventorsThomas T. Ortyl, Paul F. Skultety, Kristen C. Mitchell, Deepak S. Phadke, Faraneh Attarchi, Marguerite L. Pierce, Aaron W. Schoeneman, Joseph M. Schnitz
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Abstract
The invention provides a pharmaceutical composition in solid unit dosage form, comprising, a) a therapeutically effective amount of a piperidinoalkanol compound or a pharmaceutically acceptable salt thereof; and, b) at least one inert ingredient.
Claims25
A pharmaceutical composition in solid unit dosage form prepared by a process comprising, blending together a compound of the formula;
- ##STR10## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof, with microcrystalline cellulose, lactose and pregelatinized starch;
- adding a solution of gelatin in water with mixing;
- drying and milling the mixture;
- and adding croscarmellose sodium with mixing.
A pharmaceutical composition in solid unit dosage form prepared by a process comprising blending together a compound of the formula;
- ##STR11## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof, with microcrystalline cellulose, lactose and pregelatinized starch;
- adding a solution of gelatin in water with mixing;
- drying and milling the granulated mixture;
- adding croscarmellose sodium with mixing;
- and adding magnesium stearate with mixing.
A pharmaceutical composition in solid unit dosage form, comprising;
- a) a therapeutically effective amount of a piperidinoalkanol compound or a pharmaceutically acceptable salt thereof wherein said piperidinoalkanol compound is of the formula:
- ##STR12## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof;
- and
- b) croscarmellose sodium, microcrystalline cellulose, lactose, pregelatinized starch and gelatin in amounts of about 1% to about 10%, 20% to about 85%, 20% to about 85%, 1% to about 30% and 1% to about 15%, respectively, by weight of the composition.
A pharmaceutical composition in solid unit dosage form, comprising;
- a) a therapeutically effective amount of a piperidinoalkanol compound or a pharmaceutically acceptable salt thereof wherein said piperidinoalkanol compound is of the formula:
- ##STR13## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof;
- and
- b) croscarmellose sodium, microcrystalline cellulose, lactose, pregelatinized starch, gelatin and magnesium stearate in amounts of about 1% to about 10%, 20% to about 85%, 20% to about 85%, 1% to about 30%, 1% to about 15% and 0.05% to about 3.0%, respectively, by weight of the composition.
A pharmaceutical composition in solid unit dosage form, comprising;
- a) a therapeutically effective amount of a piperidinoalkanol compound or a pharmaceutically acceptable salt thereof wherein said piperidinoalkanol compound is of the formula:
- ##STR14## wherein X is a number ranging from about zero to 5, and the individual optical isomers thereof;
- and
- b) croscarmellose sodium, microcrystalline cellulose, pregelatinized starch, and magnesium stearate in amounts of about 1% to about 10%, 20% to about 85%, 5% to about 50% and 0.05% to about 3%, respectively, by weight of the composition.
Dependencies are inferred from the claim text.