Biodegradable sustained release preparation for treating periodontitis
AssigneeDong Kook Pharmaceutical Co., Ltd.
InventorsChong Pyoung Chung, Seung Jin Lee
Life of this patent
Estimating the term…
Abstract
The present invention relates to a biodegradable sustained release preparation for treating periodontitis, especially containing polysaccharide. The core of the preparation according to the present invention consists of medicine and polysaccharide, i.e. sodium alignate, and is coated with cationic chitosan. By the function of chitosan building the coating of the preparation, the medicine is slowly released, and the carrier is completely decomposed by lysozyme in vivo after the release of the medicine.
Claims3
A method for preparing a biodegradable sustained release preparation for external use for treating periodontitis, comprising the steps of:
- gelating sodium alginate solution without active ingredient with calcium chloride solution;
- forming a capsulated microsphere by capsulating it with chitosan solution by ionic reaction between an anion thereof and a cation of said chitosan;
- and
- swelling the capsulated microsphere in a solution containing at least one active ingredient selected from the group consisting of tetracycline hydrochloride, tetracycline bases, minocycline hydrochloride, ibuprofen or flubiprofen.
Dependencies are inferred from the claim text.