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US 5,855,895 AGranted
Polyphosphazene polyelectrolyte immunoadjuvants
AssigneeVirus Research Institute
InventorsAlexander K. Andrianov, Lendon G. Payne, Jonathan R. Sargent, Sameer S. Sule
Life of this patent
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Abstract
A polyphosphazene polyelectrolyte immunoadjuvant having improved water solubility, a vaccine composition of the immunoadjuvant and an antigen or immunogen and methods of their use in producing or enhancing an immunoprotective response in a host are disclosed.
Claims27
A composition for inducing an immunogenic response in a mammal, comprising:
- an antigen and a polyphosphazene polyelectrolyte that has immunoadjuvant activity and said polyphosphazene polyelectrolyte is a copolymer having the formula:
- ##STR6## wherein each A is independently selected from X or Y in which (1) X is ##STR7## in which R.sub.1 is --O-- or --OR.sub.5 -- where R.sub.5 is a C.sub.1 -C.sub.5 alkylene moiety, R.sub.2 is at least one carboxylic acid moiety which is attached to the ring directly or through an alkylene and R.sub.3 is hydrogen or an alkoxy which is also attached to the ring;
- (2) Y is (OCH.sub.2 CH.sub.2).sub.n OR.sub.6 in which n is 1 to Z wherein Z is a number which provides an average molecular weight of 750 and R.sub.6 is a C.sub.1 to C.sub.10 hydrocarbon;
- (3) X and Y are in a range of ratios of from about 1.5:1 to about 11.5:1;
- and
- (4) m is 3 to 100,000.
3 more elements
A method of inducing an immune response in a mammal comprising the steps of
- administering to the mammal antigen and a polyphosphazene polyelectrolyte that has immunoadjuvant activity and said polyphosphazene polyelectrolyte is a copolymer having the formula:
- ##STR8## wherein each A is independently selected from X or Y in which (1) X is ##STR9## in which R.sub.1 is --O-- or --OR.sub.5 -- where R.sub.5 is a C.sub.1 -C.sub.3 alkylene moiety, R.sub.2 is at least one carboxylic acid moiety which is attached to the ring directly or through an alkylene and R.sub.3 is hydrogen or an alkoxy which is also attached to the ring;
- (2) Y is (OCH.sub.2 CH.sub.2).sub.n OR.sub.6 in which n is 1 to Z wherein Z is a number which provides an average molecular weight of 750 and R.sub.6 is a C.sub.1 to C.sub.10 hydrocarbon;
- (3) X and Y are in a range of ratios of from about 1.5:1 to about 11.5:1;
- and
- (4) in is 3 to 100,000;
- thereby inducing an immune response in said mammal.
4 more elements
A polyphosphazene polyelectrolyte adjuvant which has immunoadjuvant activity and is a copolymer having the formula:
- ##STR10## wherein each A is independently selected from X or Y in which (1) X is ##STR11## in which R.sub.1 is --O-- or --OR.sub.5 -- where R.sub.5 is a C.sub.1 -C.sub.3 alkylene moiety, R.sub.2 is at least one carbolic acid moiety which is attached to the ring dry or through an alkylene and R.sub.3 is hydrogen or an alkoxy which is also attached to the ring;
- (2) Y is (OCH.sub.2 CH.sub.2).sub.n OR.sub.6 in which n is 1 to Z wherein Z is a number which provides an average molecular weight of 750 and R.sub.6 is a C.sub.1 to C.sub.10 hydrocarbon;
- (3) X and Y are in a range of ratios of from about 1.5:1 to about 11.5:1;
- and
- (4) m is 3 to 100,000.
2 more elements
A composition for inducing an immunogenic response in an animal, comprising:
- an antigen and a polyphosphazene polyelectrolyte that has immunoadjuvant activity and is a copolymer having the formula:
- ##STR12## wherein each A is independently selected from X or Y in which (1) X is ##STR13## in which R.sub.1 is --O-- or --OR.sub.5 -- where R.sub.5 is a C.sub.1 -C.sub.3 alkylene moiety, R.sub.2 is at least one carboxylic acid moiety which is attached to he ring directly or trough an alkylene and R.sub.3 is hydrogen or an alkoxy which is also attached to the ring;
- (2) Y is selected from the group consisting of --OC.sub.2 H.sub.4 OCH.sub.3 and --OC.sub.2 H.sub.4 OC.sub.2 H.sub.4 OCH.sub.3 ;
- (3) X and Y are present in a range of ratios of from about 1.5:1 to about 11.5:1;
- and
- (4) m is 3 to 100,000.
3 more elements
Dependencies are inferred from the claim text.