US 5,855,885 A · Isolation and production of catalytic antibodies using phage technology

Abstract

Disclosed and claimed are methods for producing catalytic antibodies, including human catalytic antibodies, from bacteriophage. The methods require the cloning, selection, screening, and isolation of catalytic antibodies. Also disclosed and claimed are the products themselves, the catalytic antibodies, made from the phage technology. In addition, catalytic antibodies produced from the phage technology and useful in prodrug activation are disclosed and claimed. And finally, the invention also understands the production of catalytic antibodies to phosphonates.

Claims26

Dependent claims

A method for producing catalytic antibodies displayed on phage comprising the steps of:

(a) generating a gene library of antibody-derived domains;
(b) inserting coding for said domains into a phage expression vector;
(c) isolating said catalytic antibodies;
and
(d) wherein said phage expression vector incorporates therein a histidine peptide in tandem with a myc peptide.

2 more elements

Dependencies are inferred from the claim text.

Isolation and production of catalytic antibodies using phage technology

Life of this patent

Isolation and production of catalytic antibodies using phage technology

Life of this patent

Abstract

Claims26