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AssigneeThe Picower Institute for Medical Research
InventorsYong Ming Li, Helen Vlassara, Anthony Cerami
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The present invention is directed to methods for inhibiting the cross-linking of advanced glycosylation endproducts in a subject suspected of having elevated levels of AGEs by using the unexpected discovery that certain antibacterial proteins, in particular lysozyme and particular fragments thereof, bind to advanced glycosylation endproducts (AGEs) with high affinity, and that this binding activity is substantially noncompetitive with binding of bacterial carbohydrates to the antibacterial proteins. Accordingly, the invention relates to therapeutic methods for treating diseases and disorders associated with increased levels of AGEs, by using compositions having associated therewith a molecule having a hydrophilic loop domain, which domain is associated with AGE-binding activity, and compositions comprising such a domain to remove AGEs from biological material. The invention further relates to compositions for inhibiting the cross-linking of AGEs in a subject in need of such therapy.
A method for inhibiting cross-linking of advanced glycosylation endproducts (AGEs) in a subject suspected of having elevated levels of AGEs, comprising administering to the subject an amount of an AGE-binding molecule effective to bind AGEs and inhibit cross-linking thereof, said molecule having at least one structure corresponding to R.sub.1 Cys.sub.1 Xaa.sub.n Cys.sub.2 R.sub.2 (SEQ ID NOS:
Dependencies are inferred from the claim text.