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US 5,855,879 AGranted
Avirulent microbes and uses therefor
AssigneeWashington University
InventorRoy Curtiss III
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AssigneeWashington University
InventorRoy Curtiss III
Estimating the term…
This invention provides immunogenic compositions for the immunization of a vertebrate or invertebrate comprising an avirulent derivative of S. typhi. The derivatives having a mutation of the cya and/or crp and/or cdt genes. The invention also provides immunogenic compositions for the immunization of a vertebrate and invertebrate comprising an avirulent derivative of the above type which is capable of expressing a recombinant gene derived from a pathogen of said vertebrate or invertebrate individual to produce an antigen capable of inducing an immune response against said pathogen. Other embodiments of the invention include methods of preparing immunogenic compositions from these strains, and strains useful in the preparation of the immunogenic compositions, as well as methods of stimulating the immune system to respond to an immunogenic antigen of S. typhi by administration of the immunogenic composition.
An immunogenic composition for the immunization of an individual comprising a derivative of a pathogenic gram negative bacteria made avirulent by an inactivating mutation in a crp gene, in a pharmaceutically acceptable carrier.
An isolated gram negative bacterial strain comprising a derivative of a pathogenic gram negative bacteria made avirulent by an inactivating mutation in a crp gene wherein said derivative is capable of invading and persisting in the gut-associated lymphoid tissue or bronchus-associated lymphoid tissue.
A method of utilizing a strain of a pathogenic gram negative bacteria made avirulent by a mutation in a crp gene, the method comprising preparing an immunogenic composition by combining the strain with a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.