Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same
AssigneeThe Curators of the University of Missouri
InventorsKattesh V. Katti, Srinivasa Rao Karra, Douglas E. Berning, C. Jeffrey Smith, Wynn A. Volkert, Alan R. Ketring
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Abstract
A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises at least one functionalized hydroxyalkyl phosphine donor group and one or more sulfur or nitrogen donor and a metal combined with the ligand.
Claims19
A method for radiological imaging, said method comprising the steps of:
- administering an effective amount of a compound of the formula:
- ##STR14## wherein M.sup.R is a transition metal in a reduced state;
- X is (CHR).sub.n where (n=0, 1, 2, or 3) and R is hydrogen, carboxyl, or aromatic;
- E is N, ##STR15## where R' is hydrogen or methyl, or S;
- and Y is a hydroxyalkyl phosphine of the formula P(A--OH).sub.n where (n=1, 2, or 3) and where A is --CH.sub.2, --C.sub.2 H.sub.4, or iso- or normal-C.sub.3 H.sub.6 -- and detecting for presence of the compound.
A method of making a multi-dentate ligand-metal complex, said method including the following reactions:
- ##STR16## wherein, M is a transition metal, M.sup.R is a transition metal in a reduced state;
- X is (CHR).sub.n where (n=0, 1, 2, or 3) and R is hydrogen, carboxyl, or aromatic;
- E is N, ##STR17## where R' is hydrogen or methyl, or S;
- and Y is a hydroxyalkyl phosphine of the formula P(A--OH).sub.n where (n=1, 2, or 3) and where A is --CH.sub.2, --C.sub.2 H.sub.4, or iso- or normal --C.sub.3 H.sub.6 --.
A multi-dentate ligand for use in constructing therapeutic and diagnostic radiopharmaceuticals, said ligand having the structure:
- ##STR18## wherein X is (CHR).sub.n where (n=0, 1, 2, or 3) and R is hydrogen, carboxyl, or aromatic;
- E is N, ##STR19## where R' is hydrogen or methyl, or S;
- and Y is a hydroxyalkyl phosphine of the formula P(A--OH).sub.n where (n=1, 2, or 3) and where A is --CH.sub.2, --C.sub.2 H.sub.4, or iso- or normal --C.sub.3 H.sub.6 --.
Dependencies are inferred from the claim text.