Method for making encapsulated gas microspheres from heat denatured protein in the absence of oxygen gas
AssigneeMolecular Biosystems, Inc.
InventorsKarel J. Lambert, Sheila Benay Podell, Edward G. Jablonski, Carl Hulle, Kenneth Hamilton, Rolf Lohrmann
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Abstract
Elastic protein microspheres, filled with water insoluble gases, have been produced by ultrasound and mechanical cavitation without the present of oxygen. The microspheres are highly echogenic. The microspheres exhibit greatly enhanced static pressure stability, up to 40 psig. The microspheres are resistant to coalescence and to expansion due to differential gas diffusion. The microspheres are resistant to collapse when suspended in a gas-depleted aqueous solution.
Claims7
A method of making encapsulated gas microspheres useful as an ultrasonic imaging agent comprising subjecting a mixture of an aqueous solution of a filmogenic protein and a pharmacologically acceptable insoluble gas to ultrasonic or mechanical cavitation in the absence of oxygen gas.
Dependencies are inferred from the claim text.