Tricyclic pteridinones and a process for their preparation
AssigneeSchering Corporation
InventorsDavid Daniel Davey, John William Lampe
Life of this patent
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Abstract
This invention relates to novel tricyclic pteridinones, their aza analogs and their pharmaceutically acceptable salts. Further encompassed by the invention is a novel process for the production of the tricyclic pteridinones and their aza analogs. The compounds of the invention exhibit cardiovascular properties, particularly mixed vasodilation and selective venous and arterial dilation. Pharmaceutical compositions are proposed for the compounds.
Claims29
A compound which is 9-ethyl-4-N-(2-(pyridin-2-yl)ethyl)-methylamino!imidazo5,1-h!pteridin-6( 5H)-one.
A compound which is 9-ethyl-4-(1-methylpiperdin-4-yl)-methylamino!imidazo5,1-h!pteridin-6(5H )-one.
A compound which is 9-ethyl-4-N-(phenylmethyl)-methylamino!imidazo5,1-h!pteridin-6(5H)-one.
A compound which is 9-ethyl-4-(methylamino)imidazo-5,1-h!pteridin-6(5H)-one.
A compound which is 9-ethyl-7-methyl-4-N-(2-(dimethylamino)ethyl)methylamino!imidazo5,1-h!pt eridin-6(5H)-one.
A compound which is 9-ethyl-4-(1-methylpiperidin-4-yl)-amino!imidazo5,1-h!pteridin-6(5H)-one .
A compound which is 9-ethyl-4-(2-hydroxyethyl)methylamino!imidazo5,1-h!pteridin-6(5H)-one.
A compound which is 9-ethyl-2-(2-ethyl-4-methyl-1H-imidazol-1-yl)-4,7-dimethylimidazo5,1-h!pt eridin-6(5H)-one.
A compound which is 9-ethyl-4-(2-hydroxyethyl)amino!-7-methylimidazo5,1-h!pteridin-6(5H)-one .
A compound which is 4,9-diethyl-2-(2-ethyl-4-methyl-1H-imidazol-1-yl)-7-methylimidazo5,1-h!pt eridin-6(5H)-one.
A compound which is 9-ethyl-2-(2-ethyl-4-methyl-1H-imidazol-1-yl)-7-methyl-4-(2-propyl)imidazo 5,1-h!pteridin-6(5H)-one.
A compound which is 9-ethyl-2-(methylsulfonyl)-4-(N-phenylmethyl)methylamino!imidazo5,1-h!pt eridin-6(5H)-one.
A compound which is 9-ethyl-2-(2-diethylamino)ethyl!-amino!-4-(N-phenylmethyl)methylamino!i midazo5,1-h!pteridin-6(5H)-one.
A compound which is 9-ethyl-2-(2-diethylamino)ethyl!-amino-4-methylaminoimidazo5,1-h!pteridi n-6(5H)-one.
A compound which is 4-(dimethylamino)-9-((morpholin-4-yl)methyl)imidazo5,1-h!pteridin-6(5)-on e.
A compound which is 9-ethyl-7-methyl-4-(dimethylamino)-imidazo5,1-h!pteridin-6(5H)-one.
A compound which is 9-ethyl-7-methyl-4-(dimethylamino)-2-methylthioimidazo5,1-h!pteridin-6(5H )-one.
A compound which is 9-ethyl-7-methyl-4-(dimethylamino)-2-(methylsulfonyl)imidazo5,1-h!pteridi n-6(5H)-one.
A compound which is 4,9-diethyl-2-(2-ethyl-1H-imidazol-1-yl)imidazo5,1-h!pteridin-6(5H)-one.
A compound which is 4,9-diethyl-2-(1H-imidazol-1-yl)-imidazo5,1-h!pteridin-6(5H)-one.
A compound which is 9-ethyl-2-(2-ethyl-1H-imidazol-1-yl)-4-propylimidazo5,1-h!pteridin-6(5H)- one.
A compound which is 9-ethyl-2-(1H-imidazol-1-yl)-4-propylimidazo5,1-h!pteridin-6(5H)-one.
A compound which is 9-ethyl-4-(2-(diethylamino)ethyl)-amino-7-methylimidazo5,1-h!pteridin-6(5 H)-one.
A compound which is 4,7-dimethyl-9-ethyl-2-(methylsulfonyl)imidazo5,1-h!pteridin-6(5H)-one.
A compound which is 4-(1-methylpiperidin-4-yl)-methylamino!-8-phenylimidazo2,1-h!pteridin-6( 5H)-one.
A compound which is 4-ethyl-2-(1H-imidazol-1-yl)-imidazo2,1-h!pteridin-6(5H)-one.
A compound which is 2-(1H-imidazol-1-yl)-4-(2-propyl)-imidazo2,1-h!pteridin-6(5H)-one.
A compound which is 8-ethyl-4-(2-(diethylamino)ethyl)-amino!imidazo2,1-h!pteridin-6(5)-one.
A compound which is 9-ethyl-4-(2-(diethylamino)ethyl)-amino!imidazo2,1-h!pteridin-6(5H)-one.
Dependencies are inferred from the claim text.