Process for acylating the 1-position of saccharides
AssigneesEnsuiko Sugar Refining Co., Ltd., Tadakatsu Mandai
InventorsTadakatsu Mandai, Hiroshi Okumoto, Koji Hara, Katsuhiko Mikuni, Kozo Hara, Hiroki Hamada
Life of this patent
Estimating the term…
Abstract
A sugar derivative wherein a hydroxy-carboxylic acid is combined to a position 1 of a sugar via ether linkage, and other hydroxyl groups are protected with a protective groups. A method of producing the sugar derivative, comprises allowing glycolic ester to react with a compound so as to combine said glycolic ester at the position 1 of the sugar skeleton, and then saponifying, said compound has on the position 1 any of hydroxyl group, halogen atom and sulfur atom with a substitutent group, and has other hydroxyl groups being protected with a protective groups.
Claims12
A method of producing a sugar derivative having a hydroxy-carboxylic acid residue bonded to the 1-position of the sugar via the hydroxyl group thereof, comprising:
- (a) reacting a hydroxy-carboxylic acid ester with a sugar having a hydroxyl group or a halogen atom at the 1-position thereof, to form an ether linkage between the hydroxyl group of the hydroxy-carboxylic acid ester and the carbon atom at the 1-position of the sugar,
- wherein, when the sugar has other hydroxyl groups, said other hydroxyl groups are protected as benzyl ethers;
- and
- (b) saponifying said ester.
Dependencies are inferred from the claim text.