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AssigneesBioelastics Research, Ltd., The UAB Research Foundation
InventorsDan W. Urry, David T. McPherson, Jie Xu
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A method for purifying an artificial polymer that exhibits a reversible inverse temperature transition is provided. The method involves (a) dissolving the polymer in an aqueous medium so that the temperature of the medium is below the effective transition temperature; (b) adjusting the temperature of the aqueous medium relative to the effective transition temperature of the polymer; (c) removing any particulate material from the medium; (d) adjusting the temperature of the aqueous medium relative to the effective transition temperature of the polymer so that the temperature of the medium is above the effective transition temperature; (e) collecting the polymer from the medium as a more dense phase; and (f) optionally repeating any of steps (a)-(e) until a desired level or purity is reached; with the proviso the order of steps can be (a)-(d)-(e)-(a)-(b)-(c).
A method for purifying a bioelastic polymer comprising pentapeptide or tetrapeptide repeating units, wherein said repeating units exist in a conformation having a .beta.-turn and said polymer exhibits a reversible inverse temperature transition, comprising:
Dependencies are inferred from the claim text.