Aliphatic polyesters of trimethylene carbonate epsilon-caprolactone and glycolide
AssigneeEthicon, Inc.
InventorsModesto Erneta, Idrish A. Vhora
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Abstract
Absorbable, segmented copolymers of aliphatic polyesters based on lactone monomers glycolide, trimethylene carbonate and .epsilon.-caprolactone are described. The segmented copolymers exhibit a broad range of properties, especially high strength, low modulus and fast in vivo absorption, useful in a variety of medical devices. The copolymers of the present invention have such properties, making them useful in medical devices for plastic surgery indications.
Claims14
An absorbable, biocompatible segmented copolymer comprising:
- a prepolymer containing repeating units obtained from trimethylene carbonate, glycolide and .epsilon.-caprolactone monomers, wherein the mole percent of trimethylene carbonate is in the range of from about 2 to about 40;
- the mole percent of glycolide is in the range of from about 2 to about 55 mole percent and the mole percent of .epsilon.-caprolactone is in the range of from about 2 to about 40 mole percent;
- copolymerized with in the range of from about 10 mole percent to about 80 mole percent of repeating units of glycolide;
- wherein the mole percentages are based on the total moles of monomer in the segmented copolymer.
An absorbable medical device formed from an absorbable, biocompatible segmented copolymer comprising:
- a prepolymer containing repeating units obtained from trimethylene carbonate, glycolide and .epsilon.-caprolactone monomers, wherein the mole percent of trimethylene carbonate is in the range of from about 2 to about 40;
- the mole percent of glycolide is in the range of from about 2 to about 55 mole percent and the mole percent of .epsilon.-caprolactone is in the range of from about 2 to about 40 mole percent;
- copolymerized with in the range of from about 10 mole percent to about 80 mole percent of repeating units of glycolide;
- wherein the mole percentages are based on the total moles.
A medical device coated with a segmented copolymer comprising:
- a prepolymer containing repeating units of trimethylene carbonate, glycolide and .epsilon.-caprolactone, wherein the mole percent of trimethylene carbonate is in the range of from about 2 to about 40;
- the mole percent of glycolide is in the range of from about 2 to about 55 mole percent and the mole percent of .epsilon.-caprolactone is in the range of from about 2 to about 40 mole percent;
- copolymerized with in the range of from about 10 mole percent to about 80 mole percent of glycolide;
- wherein the mole percentages are based on the total moles of monomer in the segmented copolymer.
A drug delivery matrix comprising a drug and a segmented polymer formed from:
- a prepolymer containing repeating units of trimethylene carbonate, glycolide and .epsilon.-caprolactone, wherein the mole percent of trimethylene carbonate is in the range of from about 2 to about 40;
- the mole percent of glycolide is in the range of from about 2 to about 55 mole percent and the mole percent of .epsilon.-caprolactone is in the range of from about 2 to about 40 mole percent;
- copolymerized with in the range of from about 10 mole percent to about 80 mole percent of glycolide;
- wherein the mole percentages are based on the total moles of monomer in the segmented copolymer.
Dependencies are inferred from the claim text.