Use of lactide polymers for adhesion prophylaxis
OwnerChristian Jurgens, Hans Ryefger-Kricheldorf +1inventors
InventorsChristian Jurgens, Hans Ryefger-Kricheldorf, Ingrid Kreiser-Saunders
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Abstract
The invention relates to the use of absorbable physiologically acceptable sheets of copolymers for preventing postoperative adhesions after surgical procedures and is characterized in that the sheets consist of racemic lactide and .epsilon.-caprolactone, .sigma.-valerolactone, .tau.-decalactone or .beta.-hydroxybutyric acid, prepared by reacting the monomers in the molar ratio of lactide to partner in the reaction of from 90 to 70 30 to 10 with the addition of metal carboxylates which are known per se as initiator, with a ratio of partner in the reaction to initiator of from 300:1 to more than 1000:1 at temperatures of 130.degree.-150.degree. C. over a period of 24 to 96 hours.
Claims12
Physiologically acceptable sheets of copolymers for preventing postoperative adhesion after surgical procedures, wherein the copolymers are prepared by reacting racemic lactide and a monomeric compound selected from the group consisting of .epsilon.-caprolactone, .sigma.-valerolactone, .tau.-decalactone and .beta.-hydroxybutyric acid, in the molar ratio of lactide to monomeric compound of from 90 to 70:30 to 10 and wherein the reaction is carried out in the presence of tin-II-diethylhexanoate initiator in a ratio of total monomer in the reaction to initiator of from 300:1 to more than 1000:1 at a temperature of between 130.degree.-150.degree. C. over a period of 24 to 96 hours.
A method of using an absorbable physiologically acceptable sheet of copolymers for preventing postoperative adhesions after surgical procedures which comprises applying said sheet to tissue, wherein the copolymers are prepared by reacting racemic lactide and a monomeric compound selected from the group consisting of .epsilon.-caprolactone, .sigma.-valerolactone, .tau.-decalactone and .beta.-hydroxybutyric acid, in the molar ratio of lactide to monomeric compound of from 90 to 70:30 to 10 with the addition of metal carboxylates as initiator, with a ratio of total monomer in the reaction to initiator of from 300:1 to more than 1000:1 at a temperature of between 130.degree.-150.degree. C. over a period of 24 to 96 hours.
Dependencies are inferred from the claim text.