Protein kinase inhibitor
AssigneeNatpro, Inc.
InventorsSubramaniam Sriram, John Bright, Bishwajit Nag, Somesh D. Sharma
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Abstract
A compound of the formula I ##STR1## wherein A and C are independently H, alkyl of 1-6 carbon atoms, hydroxy, or alkoxy of 1-6 carbon atoms; B is hydroxy or alkoxy of 1-6 carbon atoms; and Y is cyano, ##STR2## --C(NR.sub.1 R.sub.2).dbd.C(CN).sub.2 ; wherein X=O or S, and R.sub.1 and R.sub.2 are independently H, benzyl, --CH(CH.sub.3), C.sub.6 H.sub.5 --(CH.sub.2).sub.n C.sub.6 H.sub.6, phenyl; --CO.sub.2 R; n=2-4; R is lower alkyl of 1-6 carbon atoms is used for treating inflammation and immunological diseases.
Claims7
A method for treating inflammation in a patient suffering from an inflammatory condition comprising the step of administering a therapeutically effective amount of a compound of the formula:
- ##STR5## wherein A and C are H, B is methoxy;
- and
- Y is cyano, ##STR6##
- --C(NR.sub.1 R.sub.2).dbd.C(CN).sub.2 ;
- wherein X=O or S, and R.sub.1 and R.sub.2 are independently H, benzyl, --CH(CH.sub.3), C.sub.6 H.sub.5
- --(CH.sub.2).sub.n C.sub.6 H.sub.5, phenyl;
- n=2-4;
- R is lower alkyl of 1-6 carbon atoms.
A method for treating an immunological disease in a patient afflicted with said disease comprising the step step of administering a therapeutically effective amount of a compound of the formula:
- ##STR7## wherein A and C are H, B is methoxy;
- and
- Y is cyano, ##STR8##
- --C(NR.sub.1 R.sub.2).dbd.C(CN).sub.2 ;
- wherein X=O or S, and R.sub.1 and R.sub.2 are independently H, benzyl, --CH(CH.sub.3), C.sub.6 H.sub.5
- --(CH.sub.2).sub.n C.sub.6 H.sub.5, phenyl;
- n=2-4;
- R is lower alkyl of 1-6 carbon atoms.
Dependencies are inferred from the claim text.