Preparation of chlorinated paclitaxel analogues and use thereof as antitumor agents
AssigneeXechem International, Inc.
InventorsRamesh C. Pandey, Luben K. Yankov, Raghu Nair, Alex Poulev
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Abstract
Provided are novel paclitaxel analogues which are selectively chlorinated stereospecific derivatives of cephalomannine and 7-epi-cephalomannine having paclitaxel-like antitumor efficacy, methods for their preparation and methods for treating tumors with these compounds.
Claims15
A compound of the formula, ##STR14## wherein R is selected from the group consisting of:
- ##STR15##
A method for the production of a compound of the formula, ##STR20## wherein R is selected from the group consisting of, ##STR21## comprising chlorinating cephalomannine and/or 7-epi-cephalomannine under conditions effective to selectively chlorinate the unsaturated 2", 3" side-chain portion of cephalomannine and/or 7-epi-cephalomannine.
Dependencies are inferred from the claim text.