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US 5,854,269 AGranted
Nasal spray compositions
AssigneeSchering-Plough Healthcare Products, Inc.
InventorsJoseph A. Haslwanter, William Rencher
Life of this patent
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Abstract
An aqueous nasal decongestant composition containing oxymatazoline is disclosed which does not contain mercurial preservatives.
Claims8
An aqueous, topical, nasal decongestant composition comprising an amount of oxymetazoline or a pharmaceutically acceptable salt thereof sufficient to effect nasal decongestion and an aqueous carrier comprising:
- 70 to 90% by weight/volume of water;
- 0.10 to 5.00% by weight/volume of an aromatic alcohol;
- 0.01 to 0.3% by weight/volume of a non-mercurial antimicrobial preservative;
- 0 to 10% by weight/volume of a moisturizing agent;
- 0 to 0.10% by weight/volume of an antioxidant;
- 0 to 2.00% by weight/volume of a surfactant;
- 0 to 0.75% by weight/volume of menthol;
- 0 to 0.15% by weight/volume of camphor;
- 0 to 0.15% by weight/volume of eucalyptol;
- a sufficient amount of a pharmaceutically acceptable buffer to maintain the pH of the composition within the range of about 4.00 to 8.00;
- and
- QS water,
- said composition being free of mercurial antimicrobial preservatives.
10 more elements
Dependencies are inferred from the claim text.