Naphthyridinone derivatives
AssigneeKnoll, Inc.
InventorsBernard John Armitage, Bruce William Leslie
Life of this patent
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Abstract
Compounds of formula I ##STR1## including pharmaceutically acceptable salts thereof in which R.sub.1 represents a phenyl C.sub.1-6 alkyl group (in which the phenyl ring is optionally substituted by one or more of the following: halo, a C.sub.1-4 alkyl group, a C.sub.1-4 alkoxy group, hydroxy or trifluoromethyl) and the alkyl chain is optionally substituted by one or more C.sub.1-2 alkyl groups; R.sub.2 represents a C.sub.2-6 alkoxycarbonyl group; and R.sub.3 represents hydrogen or halo are disclosed, which are antirheumatic agents and are useful as modulators of cytokine synthesis, immunomodulatory agents, antiinflammatory agents and anti-allergic agents. Compositions containing these compounds and processes to make these compounds are also disclosed.
Claims7
A compound of formula I ##STR15## or a pharmaceutically acceptable salt thereof, in which R.sub.1 represents a phenyl C.sub.1-6 alkyl group, wherein the phenyl ring is unsubstituted or is optionally substituted by one or more of the following:
- halo, a C.sub.1-4 alkyl group, a C.sub.1-4 alkoxy group, hydroxy or trifluoromethyl;
- and the alkyl chain is unsubstituted or is optionally substituted by one or more C.sub.1-2 alkyl groups;
- R.sub.2 represents a C.sub.2-6 alkoxycarbonyl group;
- and
- R.sub.3 represents halo.
A method of treating a rheumatic disease which comprises administering to a mammal suffering from the rheumatic disease a therapeutically effective amount of a compound of formula I ##STR23## or a pharmaceutically acceptable salt thereof, in which R.sub.1 represents a phenyl C.sub.1-6 alkyl group in which the phenyl ring is unsubstituted or optionally substituted by one or more of the following:
- halo, a C.sub.1-4 alkyl group, a C.sub.1-4 alkoxy group, hydroxy or trifluoromethyl and the alkyl chain is unsubstituted or optionally substituted by one or more C.sub.1-2 alkyl groups;
- R.sub.2 represents a C.sub.2-6 alkoxycarbonyl group;
- and R.sub.3 represents hydrogen or halo.
Dependencies are inferred from the claim text.