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US 5,854,246 AGranted
Topical ketoconazole emulsions
AssigneeJanssen Pharmaceutica NV
InventorsMarc Karel Jozef Francois, Eric Carolus Leonarda Snoeckx
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Abstract
The invention concerns stable emulsions comprising ketoconazole having a pH in the range from 6 to 8, characterized in that the emulsions lack sodium sulfite as an antioxidant; process of preparing said emulsions.
Claims7
A stable and less irritating oil-in-water emulsion for topical application to the skin comprising by weight based on the total weight of the emulsion:
- (a) 0.5 to 5% ketoconazole microfine;
- (b) buffer, acid or base to maintain the pH of the emulsion in the range of from 6 to 8;
- (c) sufficient dermatologically acceptable antimicrobial preservatives to prevent degradation of the emulsion;
- (d) 0.5 to 10% of a stabilizing agent which is propylene glycol;
- (e) 0.5 to 40% of a dermatologically acceptable oil;
- and
- (f) water ad 100%;
- provided that the emulsion lacks sodium sulfite as an anti-oxidant.
5 more elements
Dependencies are inferred from the claim text.