Melamine derivatives for use in the treatment of cancer
AssigneeCancer Research Campaign Technology Limited
InventorsMichael Jarman, Helen Mary Coley
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Abstract
The present invention provides compounds of the formula (I) wherein each R.sup.1, which may be the same or different, is hydrogen, C.sub.1-4 alkyl, or an electron withdrawing group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH, R.sup.2 is hydrogen, C.sub.1-4 alkyl, or an electron withdrawing group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH. The compounds are analogs of trimelamol which have comparable activity but enhanced stability, and are useful as anticancer agents, particularly against ovarian cancer.
Claims8
A compound of the formula:
- ##STR4## wherein each R.sup.1, which may be the same or different, is hydrogen, C.sub.1-4 alkyl or an electron withdrawing group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH, R.sup.2 is hydrogen, C.sub.1-4 alkyl or an electron withdrawing organic group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH, with the provisos that:
- a) when each R.sup.1 is hydrogen R.sup.2 is not hydrogen, and
- b) when each R.sup.1 is methyl R.sup.2 is not hydrogen.
A method of treatment of breast cancer by tumor regression which comprises administering to a patient in need of treatment an effective amount of a compound of the formula (I). ##STR6## wherein each R.sup.1, which may be the same or different, is hydrogen, C.sub.1-4 alkyl or an electron withdrawing group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH, R.sup.2 is hydrogen, C.sub.1-4 alkyl or an electron withdrawing organic group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH, with the provisos that:
- a) when each R.sup.1 is hydrogen R.sup.2 is not hydrogen, and
- b) when each R.sup.1 is methyl R.sup.2 is not hydrogen.
A method of treatment of ovarian cancer which comprises administering to a patent in need of treatment an effective amount of a compound of formula (I) ##STR7## wherein each R.sup.1, which may be the same or different, is hydrogen, C.sub.1-4 alkyl or an electron withdrawing group selected from the group- consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH, R.sup.2 is hydrogen, C.sub.1-4 alkyl or an electron withdrawing organic group selected from the group consisting of CF.sub.3 CH.sub.2 or CH.sub.2 C.tbd.CH, with the provisos that:
- (a) when each R.sup.1 is hydrogen, R.sup.2 is not hydrogen, and
- (b) when each R.sup.1 is methyl, R.sup.2 is not hydrogen.
The method according to 6 wherein said cancer is cisplatin-resistant ovarian cancer.
Dependencies are inferred from the claim text.