Pyrido›3,2,1-I,J!›3,1!benzoxazine derivatives

A compound of the formula (I):

• ##STR75## in which R.sup.1 represents hydrogen or C.sub.1-4 -alkyl which is optionally substituted by hydroxyl or halogen;
• R.sup.2 represents hydrogen or methyl;
• R.sup.3 represents hydrogen or C.sub.1-4 -alkyl;
• R.sup.3' represents hydrogen or methyl;
• R.sup.4 represents hydrogen, C.sub.1-4 -alkyl which is optionally substituted by hydroxyl, methoxy, amino, methylamino or dimethylamino, or represents (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl;
• X.sup.1 represents hydrogen or halogen;
• Z represents a radical of the formula:
• ##STR76## in which R.sup.7 represents hydrogen, hydroxyl, --NR.sup.10 R.sup.11, hydroxymethyl, --CH.sub.2 --NR.sup.10 R.sup.11, carboxyl, inethoxycarbonyl or ethoxycarbonyl;
• in which
• R.sup.10 represents hydrogen, C.sub.1-3 -alkyl which is optionally substituted by hydroxyl, or represents C.sub.1-4 -alkoxycarbonyl or C.sub.1-3 -acyl- and
• R.sup.11 represents hydrogen or methyl;
• R.sup.8 represents hydrogen, straight-chain or branched C.sub.1-3 -alkyl, or cyclopropyl;
• R.sup.9 represents hydrogen or methyl;
• R.sup.6 represents hydrogen or methyl;
• R.sup.5 represents hydrogen, methyl, --CH.dbd.CH--CO.sub.2 R.sup.5', --CH.sub.2 --CH.sub.2 --CO.sub.2 R.sup.5', --CH.sub.2 --CO--CH.sub.3 or --CH.sub.2 --CH.sub.2 --CN;
• in which
• R.sup.5' represents methyl or ethyl;
• B represents --CH.sub.2 --, --O-- or a direct bond;
• optionally in the form a racemic mixture or a pure enantiomer thereof, and/or of a pharmaceutically utilizable hydrate or acid addition salt, alkali metal salt, alkaline earth metal salt, silver salt or guanidinium salt thereof.