Antiandrogenic agents and related pharmaceutical compositions and methods of use
AssigneeSRI International
InventorsMasato Tanabe, Wan-Ru Chao, Wesley K. M. Chong, David F. Crowe
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Abstract
Novel antiandrogenic agents are provided. An exemplary group of compounds has the structural formula (I) ##STR1## wherein R.sup.1 through R.sup.10, a and b are as defined herein. Pharmaceutical compositions and methods for using the compounds of formula (I) to treat androgen-related clinical conditions are provided, as are methods and compositions for using the compounds as contraceptive agents.
Claims13
A method for treating a clinical condition that is androgen-responsive, or is associated with androgen excess, or is both, in a mammal, comprising administering to said mammal an effective antiandrogenic amount of a compound selected from the group consisting of:
- ##STR14## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen and lower alkyl, and wherein one of R.sup.6 and R.sup.7 is hydroxyl and the other is n-propyl, or R.sup.6 and R.sup.7 are linked to provide a cycloalkyl group containing 3 to 6 carbon atoms;
- and ##STR15## wherein R.sup.5 is hydrogen or lower alkyl, and wherein R.sup.6 and R.sup.7 are linked to provide a cycloalkyl or cyclooxyalkyl ring containing 3 to 6 carbon atoms.
A method for decreasing androgen response in a mammal, comprising administering to said mammal an effective antiandrogenic amount of a compound selected from the group consisting of:
- ##STR20## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen and lower alkyl, and wherein one of R.sup.6 and R.sup.7 is hydroxyl and the other is n-propyl, or R.sup.6 and R.sup.7 are linked to provide a cycloalkyl group containing 3 to 6 carbon atoms;
- and ##STR21## wherein R.sup.5 is hydrogen or lower alkyl, and wherein R.sup.6 and R.sup.7 are linked to provide a cycloalkyl or cyclooxyalkyl ring containing 3 to 6 carbon atoms.
Dependencies are inferred from the claim text.