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US 5,854,229 AGranted
Therapeutic methods and delivery systems utilizing sex steroid precursors
AssigneeEndorecherche, Inc.
InventorFernand Labrie
Life of this patent
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AssigneeEndorecherche, Inc.
InventorFernand Labrie
Estimating the term…
Sex steroid precursors such as dehydroepiandrosterone and dehydroepiandrosterone sulphate, and compounds converted in vivo to either of the foregoing, are utilized for the treatment and/or prevention of vaginal atrophy, hypogonadism, diminished libido, osteoporosis, urinary incontinence, ovarian cancer, uterine cancer, skin atrophy, for contraception, and, in combination with an estrogen and/or progestin, for the treatment of menopause. The precursors may be formulated for percutaneous or transmucosal administration. Gels, solutions, lotions, creams, ointments and transdermal patches for the administration of these precursors are provided, as are certain pharmaceutical compositions and kits which can be used for the prevention and treatment of a wide variety of conditions related to decreased secretion of sex steroid precursors by the adrenals.
A pharmaceutical composition comprising a sex steroid precursor selected from the group consisting of DHEA, DHEA-S, and compounds converted in vivo to either, and a supplemental agent which is selected from the group consisting of an estrogen and a progestin and which in vivo will provide a serum concentration between about 4 to 13 micrograms per liter.
Dependencies are inferred from the claim text.