Antiviral phosphonomethoxyalkylene purine and pyrimidine derivatives
AssigneesInstitute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic, Rega Stichting v.z.w.
InventorsRobert W. Webb, II, Joanne J. Bronson, John C. Martin
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Abstract
A series of compounds of Formula I which have anti-tumor activity, and are useful in treating viral infections, their compositions and use. ##STR1## In Formula I B is a purine or pyrimidine base; alk.sub.1 alk.sub.2 and alk.sub.3 are chemical bonds or alkylene groups; Q is hydrogen or hydroxyl; and R.sub.1 -R.sub.4 are hydrogen or alkyl.
Claims12
The compound of Formula I ##STR21## wherein B is guanine;
- alk.sub.1 is C.sub.1-4 alkylene;
- alk2 is independently selected from a chemical bond and C.sub.1-4 alkylene;
- alk.sub.3 is a chemical bond;
- Q and R.sub.2 are hydrogen;
- R.sub.1 is independently selected from hydrogen and C.sub.1-4 alkyl and wherein one of R.sub.1 or alk.sub.2 are C.sub.1-4 alkyl or C.sub.1-4 alkylene respectively;
- R.sub.3 and R.sub.4 are independently selected from hydrogen, C.sub.1-6 alkyl, phenyl, and phenyl -C.sub.1-4 --alkylene;
- and the corresponding salts, and solvates thereof.
The compound of Formula I ##STR22## wherein B is adenine,
- alk.sub.1, alk.sub.2 and alk.sub.3 are independently selected from a chemical bond and C.sub.1-4 alkylene;
- Q is hydrogen or hydroxyl;
- R.sub.1 is R.sub.2 is hydrogen independently selected from hydrogen and C.sub.1-4 alkyl;
- R.sub.3 is alkyl, phenyl;
- R.sup.4 is H, phenyl;
- and the corresponding salts, and solvates thereof.
The compound of Formula I ##STR23## wherein B is adenine, xanthine, hypoxanthine, guanine, 8-bromoguanine, 8-chloroguanine, 8-aminoguanine, 8-hydrazinoguanine, 8-hydroxyguanine, 8-methylguanine, 8-thioguanine, 2-aminopurine, 2,6-diaminopurine, cytosine, 5-ethylcytosine, 5-methylcytosine, thymine, uracil, 5-bromouracil, 5-iodouracil, 5-ethyluracil, 5-propyluracil, 5-vinyluracil, and 5-bromovinyluracil;
- alk.sub.1, alk.sub.2 and alk.sub.3 are independently selected from a chemical bond, and C.sub.1-4 alkylene;
- Q is hydrogen;
- R.sub.1 is selected from hydrogen and C.sub.1-4 alkyl;
- R.sub.2 is hydrogen;
- and
- R.sub.3 and R.sub.4 are independently selected from hydrogen or phenyl but at least one of R.sub.3 and R.sub.4 is not hydrogen;
- and the corresponding salts, and solvates thereof.
Dependencies are inferred from the claim text.