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AssigneeThe Trustees of Columbia University in the City of New York
InventorsCy Stein, LeRoy Rabbani
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This invention provides methods of inhibiting proliferation, migration and heterotypic adhesion of vascular smooth muscle cells which comprise contacting the vascular smooth muscle cells with an amount of a phosphorothioate oligonucleotide moiety effective to inhibit the proliferation, migration or heterotypic adhesion of the vascular smooth muscle cells. This invention provides methods of inhibiting neointimal formation after balloon injury, percutaneous transluminal coronary angioplasty restenosis, and coronary artery stent restenosis in a subject which comprise administering to the subject an amount of a phosphorothioate oligonucleotide moiety effective to inhibit neointimal formation, percutaneous transluminal coronary angioplasty restenosis, or coronary artery stent restenosis in the subject. This invention further provides pharmaceutical compositions effective for treating the conditions recited above.
A method of inhibiting neointimal formation after balloon injury in a subject which comprises administering to the subject an amount of a phosphorothioate oligonucleotide moiety effective to inhibit neointimal formation, wherein the phosphorothioate oligonucleotide moiety lacks a contiguous G-guartet residue.
A pharmaceutical composition comprising a phosphorothioate oligonucleotide moiety in an amount effective to inhibit neointimal formation after balloon injury and a pharmaceutically acceptable carrier, wherein the phosphorothioate oligonucleotide moiety lacks a contiguous G-qguartet residue.
Dependencies are inferred from the claim text.