Endothelial cell proliferation inhibitor and method of use
AssigneeChildren's Medical Center Corporation
InventorsYihai Cao, M. Judah Folkman, Michael S. O'Reilly
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Abstract
The present invention comprises an endothelial inhibitor and method of use therefor. The endothelial cell proliferation inhibitor is a protein having a molecular weight of approximately 14 kD and having an amino acid sequence substantially similar to Kringle 5 of a plasminogen molecule, that has the ability to inhibit endothelial cell proliferation in in vitro assays.
Claims25
A method of inhibiting endothelial cell proliferation in vitro, comprising administering to an endothelial cell an effective amount of a protein having an amino acid sequence of a Kringle 5 peptide of a plasminogen molecule.
A method of treating an individual having an angiogenesis-mediated disease comprising, administering to the individual an effective amount of a protein having an amino acid sequence of a Kringle 5 peptide of a plasminogen molecule.
A method of inhibiting endothelial cell proliferation in an individual, comprising administering to the individual an effective amount of a protein having an amino acid sequence of a Kringle 5 peptide of a plasminogen molecule.
Dependencies are inferred from the claim text.