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AssigneePraecis Pharmaceuticals, Inc.
InventorsMark A. Findeis, Howard Benjamin, Marc B. Garnick, Malcolm L. Gefter, Arvind Hundal, Laura Kasman, Gary Musso, Ethan R. Signer, James Wakefield, Michael J. Reed
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Compounds that act to modulate the aggregation of natural .beta. amyloid peptides (.beta.-AP) are disclosed. The .beta. amyloid modulators of the invention can promote .beta.-AP aggregation or, more preferably, can inhibit natural .beta.-AP aggregation. Furthermore, the modulators are capable of altering natural .beta.-AP aggregation when the natural .beta.-APs are in a molar excess amount relative to the modulators. Pharmaceutical compositions comprising the compounds of the invention, and methods of altering natural .beta.-AP aggregation using the compounds of the invention, are also disclosed.
A method for inhibiting aggregation of natural .beta.-amyloid peptides, comprising contacting the natural .beta.-amyloid peptides with a compound such that aggregation of the natural .beta.-amyloid peptides is inhibited, said compound having a formula:
A method for treating a subject for a disorder associated with .beta.-amyloidosis, comprising:
A method for treating a subject for a disorder associated with .beta.-amyloidosis, comprising:
A method for inhibiting aggregation of natural .beta.-amyloid peptides, comprising contacting the natural .beta.-amyloid peptides with a compound comprising a retro-inverso isomer of a .beta.-amyloid peptide such that aggregation of the natural .beta.-amyloid peptides is inhibited.
A method for inhibiting aggregation of natural .beta.-amyloid peptides, comprising contacting the natural .beta.-amyloid peptides with a compound such that aggregation of the natural .beta.-amyloid peptides is inhibited, said compound having a formula:
A method for treating a subject for a disorder associated with .beta.-amyloidosis, comprising:
A method for inhibiting aggregation of natural .beta.-amyloid peptides, comprising contacting the natural .beta.-amyloid peptides with a compound such that aggregation of the natural .beta.-amyloid peptides is inhibited, said compound having a formula:
A method for treating a subject for a disorder associated with .beta.-amyloidosis, comprising:
Dependencies are inferred from the claim text.