Use of cross-linked hemoglobin in treating subarachnoid hemorrhage

A method of reducing the area of hypoperfusion after the onset of subarachnoid hemorrhage comprising administering a therapeutically effective amount of a diaspirin-crosslinked hemoglobin preparation to a mammal after the onset of subarachnoid hemorrhage in the mammal to reduce the area of hypoperfusion resulting from the subarachnoid hemorrhage.

A method of reducing or preventing post-hemorrhagic induced vasospasm following an onset of subarachnoid hemorrhage comprising systemically administering a therapeutically effective amount of a crosslinked, conjugated, encapsulated, recombinant, or polymerized, stroma-free hemoglobin preparation to a mammal after the onset of subarachnoid hemorrhage in the mammal.

A method of reducing or preventing post-hemorrhagic induced vasospasm following an onset of subarachnoid hemorrhage comprising systemically administering a therapeutically effective amount of a diaspirin-crosslinked hemoglobin preparation to a mammal after the onset of subarachnoid hemorrhage in the mammal.

A method of treating ischemic stroke before definitive diagnosis thereof comprising administering a hypervolemic, therapeutically effective amount of a diaspirin-crosslinked hemoglobin preparation to a mammal after onset of subarachnoid hemorrhage to reduce ischemic area and neuronal damage.

A method of reducing or preventing post-hemorrhagic induced vasospasm following an onset of subarachnoid hemorrhage comprising administering a therapeutically effective amount of crosslinked, stroma-free hemoglobin to a mammal after the onset of subarachnoid hemorrhage in the mammal.