Method for oxygenating tissue having reduced red blood cell flow
AssigneeBiopure Corporation
InventorsEdward E. Jacobs, Jr., Carl W. Rausch
Life of this patent
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Abstract
The present invention relates to a method of therapeutically, or prophylactically, treating a vertebrate to increase tissue oxygenation, or maintain issue oxygenation, in tissue of a vertebrate wherein the tissue has a reduced red blood cell flow, and wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance. The method comprises introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
Claims32
A method for increasing tissue oxygenation in tissue of a vertebrate, while the tissue has reduced oxygen deliver due to at least one partial obstruction of a blood vessel within the circulatory system of the vertebrate, and wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for increasing tissue oxygenation in a tissue of a vertebrate, wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, while the tissue has reduced oxygen deliver due to at least one partial obstruction of a blood vessel within the circulatory system of the vertebrate, comprising introducing, into the circulatory system of the vertebrate, at least one dose of a polymerized hemoglobin solution wherein said hemoglobin solution has:
- a) a hemoglobin concentration between about 120 grams/liter and about 140 grams/liter;
- b) a methemoglobin content less than 15 percent by weight;
- c) an oxyhemoglobin content less than or equal to 10 percent by weight;
- d) an endotoxin concentration less than 0.5 Endotoxin units per milliliter;
- e) less than, or equal to, 15 percent by weight polymerized hemoglobin with a molecular weight greater than 500,000 Daltons;
- and
- f) less than, or equal to, 10 percent by weight polymerized hemoglobin with a molecular weight less than or equal to 65,000 Daltons.
A method for increasing tissue oxygenation in tissue of a vertebrate, while the tissue has reduced oxygen delivery due to at least one partial obstruction of a blood vessel within the circulatory system of the vertebrate, and wherein the vertebrate has a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for increasing tissue oxygenation in tissue of a vertebrate, while the tissue has reduced oxygen delivery due to a decrease in a population of blood vessels associated with the tissue, and wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for increasing tissue oxygenation in tissue of a vertebrate, while the tissue has reduced oxygen delivery due to a cardiogenic dysfunction of the heart of the vertebrate, and wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for increasing tissue oxygenation in tissue of a vertebrate that is at risk for a reduction in oxygen delivery due to at least one partial obstruction of a blood vessel within the circulatory system of the vertebrate, wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for increasing tissue oxygenation in tissue of a vertebrate that is at risk for a reduction in oxygen delivery due to a decrease in a population of blood vessels associated with the tissue, wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for increasing tissue oxygenation in tissue of a vertebrate that is at risk for a reduction in oxygen delivers due to a cardiogenic dysfunction of the heart of the vertebrate, wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for increasing tissue oxygenation in tissue of a vertebrate that is at risk for a reduction in oxygen delivery due to at least one partial obstruction of a blood vessel within the circulatory system of the vertebrate, wherein the vertebrate has a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for preventing oxygen depletion in tissue of a vertebrate that is at risk for a reduction in oxygen delivery due to a decrease in a population of blood vessels associated with the tissue, wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for preventing oxygen depletion in tissue of a vertebrate that is at risk for a reduction in oxygen delivery due to a cardiogenic dysfunction of the heart of the vertebrate, wherein the vertebrate has a normovolemic blood volume and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for increasing tissue oxygenation in tissue of a vertebrate, while the tissue has reduced oxygen delivery due to a decrease in a population of blood vessels associated with the tissue, and wherein the vertebrate has a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for increasing tissue oxygenation in tissue of a vertebrate, while the tissue has reduced oxygen delivery due to a cardiogenic dysfunction of the heart of the vertebrate, and wherein the vertebrate has a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method of claim 33 wherein the cardiogenic dysfunction is selected from the group consisting of a myocardial infarction, arrhythmia, cardiomyopathy, cardioneuropathy and pericardial effusion.
A method for increasing tissue oxygenation in a tissue of a vertebrate, wherein the vertebrate has a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, while the tissue has reduced oxygen delivery due to at least one partial obstruction of a blood vessel within the circulatory system of the vertebrate, comprising introducing, into the circulatory system of the vertebrate, at least one dose of a polymerized hemoglobin solution wherein said hemoglobin solution has:
- a) a hemoglobin concentration between about 120 grams/liter and about 140 grams/liter;
- b) a methemoglobin content less than 15 percent by weight;
- c) an oxyhemoglobin content less than or equal to 10 percent by weight;
- d) an endotoxin concentration less than 0.5 Endotoxin units per milliliter;
- e) less than, or equal to, 15 percent by weight polymerized hemoglobin with a molecular weight greater than 500,000 Daltons;
- and
- f) less than, or equal to, 10 percent by weight polymerized hemoglobin with a molecular weight less than or equal to 65,000 Daltons.
A method for increasing tissue oxygenation in tissue of a vertebrate that is at risk for a reduction in oxygen delivery due to a decrease in a population of blood vessels associated with the tissue, wherein the vertebrate has a normovolemic blood volume, a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for increasing tissue oxygenation in tissue of a vertebrate that is at risk for a reduction in oxygen delivery due to a cardiogenic dysfunction of the heart of the vertebrate, wherein the vertebrate has a normovolemic blood volume, a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for preventing oxygen depletion in tissue of a vertebrate that is at risk for a reduction in oxygen delivery due to a decrease in a population of blood vessels associated with the tissue, wherein the vertebrate has a normovolemic blood volume, a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
A method for preventing oxygen depletion in tissue of a vertebrate that is at risk for a reduction in oxygen delivery due to a cardiogenic dysfunction of the heart of the vertebrate, wherein the vertebrate has a normovolemic blood volume, a major vessel hematocrit of at least about 30% and at least a normal systemic vascular resistance, comprising introducing into the circulatory system of the vertebrate at least one dose of hemoglobin.
Dependencies are inferred from the claim text.