Compounds and methods for treatment and diagnosis of prostate cancer
AssigneeCorixa Corporation
InventorsDaniel R. Twardzik, Thomas S. Vedvick
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Abstract
Compounds and methods for treating and diagnosing prostate cancer are disclosed. The compounds provided include polypeptides that contain at least a portion of a secreted or cell associated prostate cell protein. Such polypeptides may be formulated into vaccines and/or pharmaceutical compositions for immunotherapy of prostate cancer. Alternatively, or in addition, the polypeptides may be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer.
Claims2
A polypeptide comprising a portion of a prostate cell-associated antigen having the N-terminal sequence Ala-Glu-Pro-Ala-Thr-Gln-Ala-Pro-Ala-Ser-Xaa-Lys (SEQ ID NO:6), or a variant of said protein that differs only in conservative substitutions and/or modifications, wherein Xaa may be any amino acid, and wherein:
- (a) said portion demonstrates immunoreactivity with sera and/or T-cells derived from an individual with prostate cancer;
- and/or
- (b) antibodies raised against said portion are capable of detecting at least 30% of primary or metastatic human prostate tumors.
Dependencies are inferred from the claim text.