Method for testing coagulation of blood through bioactive porous partition members
AssigneeDade International Inc.
InventorsSourav K. Kundu, Ted S. Geiselman
Life of this patent
Estimating the term…
Abstract
The present invention provides methods of using bioactive porous partition members for testing the blood coagulation process or platelet function, wherein the porous partition members have an aperture and have incorporated therein at least one agent capable of initiating blood coagulation or platelet aggregation.
Claims8
A method of testing a coagulation function of blood which comprises passing blood through a device comprising a porous partition member, wherein the porous partition member has an opening and has dried therein at least one agent capable of initiating the blood coagulation process, wherein the method comprises the steps of:
- (i) providing a sample comprising blood or blood plasma to the device;
- (ii) reconstituting the agent;
- (iii) causing the sample to flow through the opening in the partition member;
- (iv) measuring the amount of time it takes for the formation of a clot at the opening in the porous partition member thereby stopping the flow of blood;
- and
- (v) correlating the time measured in step (iv) with a predetermined normal range, wherein the agent is reconstituted by providing an aqueous solution to the partition member prior to causing the sample to flow through the opening in the partition member or wherein steps (ii) and (iii) are combined and the agent is reconstituted by causing the sample to flow through the opening in the partition member.
A method of testing platelet function which comprises passing blood or platelet rich plasma through a device comprising a porous partition member, wherein the porous partition member has an opening and has dried therein at least one agent capable of activating platelet aggregation, wherein the method comprises the steps of:
- (i) providing a sample comprising blood or platelet rich plasma to the device;
- (ii) reconstituting the agent;
- (iii) causing the sample to flow through the opening in the partition member;
- (iv) measuring the amount of time it takes for the formation of a clot at the opening in the porous partition member thereby stopping the flow of blood;
- and
- (v) correlating the time measured in step (iv) with a predetermined normal range, wherein the agent is reconstituted by providing an aqueous solution to the partition member prior to causing the sample to flow through the opening in the partition member or wherein steps (ii) and (iii) are combined and the agent is reconstituted by causing the sample to flow through the opening in the partition member.
Dependencies are inferred from the claim text.