Rathayibacter biopuresis produces cephalosporin haloperoxidase
AssigneeBiopure Corporation
InventorsBing L. Wong, Yong-Qiang Shen, Yung-Pin Chen
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Abstract
An enzyme preparation that exhibits cephalosporin haloperoxidase activity is isolatable from a microorganism species of the Rathayibacter genus. This enzyme preparation can convert cephalexin to a halogenated cephalosporin antibiotic in a single step. A particular, unique microorganism that can provide the cephalosporin haloperoxidase enzyme preparation is Rathayibacter biopuresis.
Claims6
A biologically pure culture of a microorganism which produces an enzyme preparation with cephalosporin haloperoxidase activity which catalyzes the replacement reaction at the three position of the cephalosporin .beta.-lactam ring system with a halogen.
A biologically pure culture of a microorganism which produces an enzyme preparation with cephalexin haloperoxidase activity which catalyzes the replacement reaction at the three position of the cephalexin .beta.-lactam ring system with halogen.
Dependencies are inferred from the claim text.