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AssigneeThe Institute of Physical and Chemical Research
InventorsShuichi Tsuji, Nobuyuki Kurosawa, Toshiro Hamamoto, Young-Choon Lee, Takashi Nakaoka, Naoya Kojima
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Novel GalNAc .alpha. 2,6-sialyltransferases P-B1 and P-B3; GalNAc .alpha. 2,6-sialyltransferase genes encoding the above GalNAc .alpha. 2,6-sialyltransferases P-B1 and P-B3; and an extracellularly releasable protein catalyzing GalNAc .alpha. 2,6-sialic acid transfer which comprises a polypeptide portion as being an active domain of the GalNAc .alpha. 2,6-sialyltransferase P-B1 or P-B3 together with a signal peptide are provided. Also provided is a process for preparing a sialyltransferases which enables efficient recovery of a sialyltransferase expressed in a large quantity in microorganisms.
An extracellularly releasable recombinant fusion protein comprising the active domain of a GalNAc .alpha. 2,6-sialyltransferase and a signal peptide.
An extracellularly releasable recombinant fusion protein, comprising the active domain of GalNAc .alpha. 2,6-sialyltransferase and a signal peptide, wherein said signal peptide is located on the N-terminal side of the active domain and replaces the hydrophobic segment of the GalNAc .alpha. 2,6-sialyltransferase.
Dependencies are inferred from the claim text.