Sesquiteterpenic dervatives
AssigneeGruppo Lepetit S.p.A.
InventorsStefania Stefanelli, Federica Sponga, Khalid Islam, Maurizio Denaro, Pietro Ferrari
Life of this patent
Estimating the term…
Abstract
The present invention concerns novel compounds obtained by fermenting a microorganism of the genus Memnonoiella or Stachybotrys, which compounds are inhibitors of the enzyme inositol monophosphatase (EC 3.1.3.25). The present invention also relates to the use of these novel compounds in treating manic depression and pharmaceutical formulations comprising said compounds as active ingredient; a further object is the use of these compounds in an analytical method for detecting inositol monophosphatase.
Claims12
A Sesquiterpenic compound having the following physico-chemical characteristics:
- A)Ultraviolet absorption spectrum:
- ______________________________________ Solvent Lambda max (nm) ______________________________________ MeOH 222, 284 0.1 M KOH 231, 291, 334 ______________________________________
- B) Positive ion FAB spectrum on a Finnigan TSQ 700 triple stage quadrupole mass spectrometer;
- saddle field atom gun with Xe gas at 8 kV voltage and 0.23 mA current;
- glycerol/water matrix:
- Major FAB/MS peak determined at 387 (MH+)
- C) R.sub.f value of 0.48 in the following TLC system:
- hexane:acetone, 6:4 (v/v) on silica gel
- D) NMR spectra recorded in CDCl.sub.3 with a Bruker AM 500 instrument, using TMS as internal standard (.delta.,ppm=0), (s=singlet;
- d=doublet;
- br s=broad singlet;
- m=multiplet):
- 1H-NHR recorded at 500 MHz, (.delta.,ppm):
- 10.65 s, 10.40 s, 6.94 s, 3.41 br s, 3.19 d, 2.84 d, 2.00-1.72 m, 1.70-1.40 m, 1.02 2 m,0.89 s, 0.77 s;
- .sup.13 C-NMR recorded at 125.76 MHz, (.delta.,ppm):
- 193.5, 188.6, 167.6, 157.5, 138.1, 119.5, 111.5, 109.1, 100.7, 75.7, 42.3, 40.1, 37.6, 37.1, 31.2, 30.7, 28.3, 24.7, 24.2, 22.3, 21.0, 16.1, 15.5.
A Sesquiterpenic compound having the following physico-chemical characteristics:
- A) Ultraviolet absorption spectrum:
- ______________________________________ Solvent Lambda max (nm) ______________________________________ MeOH <200, 275 0.1 M KOH <200, 282, 337 ______________________________________
- B) Positive ion FAB spectrum on a Finnigan TSQ 700 triple stage quadrupole mass spectrometer;
- saddle field atom gun with Xe gas at 8 kV voltage and 0.23 mA current;
- glycerol/water matrix:
- Major FAB/MS peak determined at 403 (MH+)
- C) R.sub.f value of 0.23 in the following TLC system:
- hexane:acetone, 6:4 (v/v) on silica gel.
A Compound of formula IV ##STR5## wherein R and R.sup.1 represent both a --CHO moiety or one of R or R.sup.1 represents a --CHO moiety and the other represents a --COOH moiety.
Dependencies are inferred from the claim text.