Compositions comprising IL-11 and methods of making and using IL-11
AssigneeGenetics Institute, Inc.
InventorsYu-Chung Yang, Frances K. Bennett, Stephan R. Paul
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Abstract
A novel mammalian cytokine, IL-11, and processes for producing it are disclosed. IL-11 may be used in pharmaceutical preparations for stimulating and/or enhancing cells involved in the immune response and cells involved in the proper functioning of the hematopoietic system.
Claims24
An IL-11 produced by a method comprising the steps of:
- (a) culturing a host cell transformed with a DNA molecule which hybridizes under stringent wash conditions of 0.1.times.SSC at 65.degree. C. to a complement of the DNA encoding an IL-11 having an amino acid sequence comprising amino acids 22 through 199 of SEQ ID NO:2;
- and
- (b) recovering said IL-11.
Purified IL-11 encoded by an isolated DNA molecule comprising a DNA molecule selected from the group consisting of the DNA molecules of ATCC deposit numbers 68284 and 68172.
Purified IL-11 encoded by a DNA molecule which hybridizes under stringent wash conditions of 0.1.times.SSC at 65.degree. C. to a complement of the DNA encoding an IL-11 having an amino acid sequence comprising amino acids 22 through 199 of SEQ ID NO:2.
A method of modulating the function of a cytokine comprising administering IL-11 encoded by a DNA molecule which hybridizes under stringent wash conditions of 0.1.times.SSC at 65.degree. C. to a complement of the DNA encoding an IL-11 having an amino acid sequence comprising amino acids 22 through 199 of SEQ ID NO:2.
Dependencies are inferred from the claim text.