Hepatitus B vaccine
AssigneeImperial College of Science, Technology and Medicine
InventorsHoward Christopher Thomas, William Frederick Carman
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Abstract
A variant HBsAg protein of fragment thereof displaying the antigenicity of Hepatitis B virus surface antigen is disclosed, in which the variant protein or fragment thereof (vHBsAg) comprises a modified `a` determinant in which there is an amino acid other than glycine at position 145 of the HBsAg sequence. A vaccine comprising the vHBsAg is provided, as is a kit for diagnostic in vitro detection of anti-vHBsAg antibodies and an antibody preparation comprising anti-vHBsAg antibodies.
Claims10
A composition comprising a DNA sequence encoding a variant hepatitis BS (vHBsAg) protein or fragment thereof, said vHBsAg protein comprising a modified `a` determinant of an S (HBs) protein in which the amino acid at position 145 of the HBs protein is arginine, said vHBsAg displaying an antigenicity different from that of wild-type S (HBsAg) protein, said DNA being in admixture with a suitable carrier or diluent.
Dependencies are inferred from the claim text.