Polynucleotides encoding human S-adenosyl-5-homocysteine hydrolase derived from bladder
AssigneeIncyte Pharmaceuticals, Inc.
InventorsJennifer L. Hillman, Neil C. Corley, Preeti Lal, Purvi Shah
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Abstract
The invention provides a human S-adenosyl-5-homocysteine hydrolase (SAHH) and polynucleotides which identify and encode SAHH. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of SAHH.
Claims10
An isolated and purified polynucleotide sequence encoding human S-adenosyl-5-homocysteine hydrolase comprising the amino acid sequence of SEQ ID NO:1 or fragments of SEQ ID NO:1 having hydrolase activity.
An isolated and purified polynucleotide sequence comprising SEQ ID NO:2.
A method for producing a polypeptide comprising the amino acid sequence of SEQ ID NO:1, or fragments of SEQ ID NO:1 having hydrolase activity, the method comprising the steps of:
- a) culturing the host cell of claim 10 under conditions suitable for the expression of the polypeptide;
- and
- b) recovering the polypeptide from the host cell culture.
Dependencies are inferred from the claim text.