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US 5,854,007 AGranted
Process for producing GM1 specific antibodies
AssigneeLudwig Institute for Cancer Research
InventorsGerd Ritter, Lloyd J. Old
Life of this patent
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Abstract
The invention relates to the production of ganglioside specific antibodies. These antibodies are produced following immunization with lipopolysaccharide antigen of Campylobacter jejuni. The antibodies bind to monosialogangliosides, including GM2 and GM1.
Claims11
A process for making an antibody which binds to monosialoganglioside GM1, comprising:
- (i) immunizing a subject animal with an antigen comprising the structure:
- Gal.beta.1.fwdarw.3Gal NAc.beta.1.fwdarw.4Gal (II.sup.3 NeuAc)
- in an amount sufficient to provoke production of antibody by said animal with the proviso that the antigen is not GM1, and
- (ii) isolating the antibodies produced by said animal.
1 more element
A process for making an antibody which binds to monosialoganglioside GM1, comprising:
- (i) immunizing a subject animal with a purified lipopolysaccharide obtained from a gram negative bacteria which comprises the structure:
- Gal .beta.1-3GalNAc.beta.1-4Gal.beta. (II3neuAc) in an amount sufficient to provoke production of antibody by said animal, and
- (ii) isolating the antibodies produced by said animal.
Dependencies are inferred from the claim text.