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AssigneesAlteon Inc., The Picower Institute for Medical Research
InventorsRichard J. Bucala, Helen Vlassara, Anthony Cerami, Henry W. Founds
Estimating the term…
Methods are disclosed for measuring the accumulation of advanced glycosylation endproducts (AGEs), which are predicated on the discovery that such AGEs are present in tobacco and its byproducts. More particularly, the methods focus on the observation that individuals who smoke or otherwise use tobacco have increased levels of AGEs over non-smoking individuals. The present methods relate to the measurement of AGE levels in both individuals and in tobacco and its byproduct, smoke. Methods are also disclosed for the evaluation of the tobacco products to determine their storage status and organoleptic capacity and potential, as well as for the treatment of the ambient to lower AGE levels. For example, air or other samples may be taken and evaluated by a dosimeter or like device, to determine whether AGE levels exceed normal, after which measures could be implemented to remediate the ambient condition. All such methods and corresponding materials are contemplated and included.
A method for measuring the history of tobacco smoking, if any, in a human subject, comprising measuring the serum levels of advanced glycosylation endproducts (AGEs) or substances exhibiting immunoreactivity of AGEs in said subject, and comparing the results of said measurements to a pooled standard taken from non-smoking individuals of similar medical history.
A method for measuring the exposure of an individual to advanced glycosylation endproducts (AGEs) or substances exhibiting immunoreactivity of AGEs during tobacco smoking comprising measuring said AGEs or said substances in tobacco or in the volatilized combustion products thereof.
A method for determining the organoleptic potential of tobacco comprising measuring the presence and amount of advanced glycosylation endproducts (AGEs) or substances exhibiting immunoreactivity of AGEs in said tobacco.
A method for measuring the age and storage status of tobacco comprising measuring the presence and amount of advanced glycosylation endproducts (AGEs) or substances exhibiting immunoreactivity of AGEs in tobacco.
A method for determining the organoleptic potential of tobacco comprising measuring the presence and amount of advanced glycosylation endproducts (AGEs) or substances exhibiting immunoreactivity of AGEs in the smoke produced by the combustion of said tobacco.
A method for measuring the age and storage status of tobacco comprising measuring the presence and amount of advanced glycosylation endproducts (AGEs) or substances exhibiting immunoreactivity of AGEs in the smoke produced from the combustion of said tobacco.
A method for determining the commercial value of a particular tobacco crop comprising determining the organoleptic potential of tobacco and measuring its age and storage status by measuring the presence and amount of advanced glycosylation endproducts (AGEs) or substances exhibiting immunoreactivity of AGEs in a sample thereof.
A method for detecting the presence and amount of advanced glycosylation endproducts (AGEs) or substances exhibiting immunoreactivity of AGEs in an individual who smokes tobacco, comprising:
A method for the generation of antibodies enriched for reactivity with advanced glycosylation endproducts or moieties exhibiting immunoreactivity of AGEs present in tobacco and its combustion byproducts including tobacco smoke, comprising immunizing an animal with an immunogen selected from tobacco;
Dependencies are inferred from the claim text.