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US 5,853,988 AGranted
Diagnosis of retinoblastoma
AssigneesMassachusetts Eye and Ear Infirmary, Whitehead Institute
InventorsThaddeus P. Dryja, Stephen Friend, David W. Yandell
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Abstract
This invention relates to nucleic acid, or fragments thereof, encoding the retinoblastoma polypeptide, the retinoblastoma polypeptide itself, methods of detecting a defective retinoblastoma gene in human patients, and methods of treating these patients.
Claims55
Purified nucleic acid comprising a human retinoblastoma gene, or a fragment thereof, wherein said fragment is selected from the group consisting of:
- (a) a fragment comprising at least 20 base pairs in length, and
- (b) a nucleic acid probe comprising 15 or more bases that hybridizes specifically to said retinoblastoma gene under hybridizing conditions.
A method of using a nucleic acid of any one of claims 1, 22-36, 38-65, and 67-68 to express a polypeptide encoded by said nucleic acid.
Dependencies are inferred from the claim text.