Molecularly cloned acquired immunodeficiency syndrome polypeptides and methods of use
AssigneeGenentech, Inc.
InventorsPhillip W. Berman, Daniel J. Capon, Laurence A. Lasky
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Abstract
Diagnostic product and vaccine for Acquired Immuno-deficiency Syndrome (AIDS) and methods for making and using same, wherein viral polypeptide sequences from an AIDS associated retrovirus are expressed directly or as a fusion polypeptide in a prokaryotic or mammalian cell expression host to produce a diagnostic product which specifically binds complementary antibody produced by individuals afflicted with AIDS or a vaccine against AIDS which confers resistance to infection by AIDS associated retrovirus. The reverse transcriptase of an AIDS associated retrovirus is used separately or in a whole cell assay to identify compounds which selectively inhibit retroviral reverse transcriptase.
Claims14
A fusion polypeptide comprising (a) a first polypeptide sequence of an AIDS associated E', env, or gag polypeptide, that specifically binds complementary antibody and (b) a second polypeptide sequence which is not an AIDS associated virus polypeptide.
A fusion polypeptide having a herpes simplex virus gD signal peptide sequence fused in reading frame with a polypeptide sequence other than HSV gD.
Dependencies are inferred from the claim text.