US 5,853,975 A · Methods for identifying compositions for the treatment of body weight disorders, including obesity

Abstract

The present invention relates to methods and compositions for the treatment of body weight disorders, including, but not limited to, obesity. Specifically, the present invention identifies and describes genes which are differentially expressed in body weight disorder states, relative to their expression in normal, or non-body weight disorder states, and/or in response to manipulations relevant to appetite and/or weight regulation. Further, the present invention identifies and describes genes via the ability of their gene products to interact with gene products involved in body weight disorders and/or appetite and/or body weight regulation. Still further, the present invention provides methods for the identification and therapeutic use of compounds as treatments of body weight disorders. Additionally, the present invention describes methods for the diagnostic evaluation and prognosis of various body weight disorders, and for the identification of subjects exhibiting a predisposition to such conditions.

Claims7

Dependent claims

A method for identifying a compound that modulates C5 protein uncoupling activity, comprising:

(a) contacting a test compound to a C5 protein or a cell expressing a C5 protein;
(b) measuring the level of C5 protein uncoupling activity;
and
(c) comparing the level obtained in (b) to the C5 gene protein uncoupling activity level obtained in the absence of test compound;
such that if the level obtained in (b) differs from that obtained in the absence of test compound, a compound that modulates C5 protein uncoupling activity has been identified.

2 more elements

Dependencies are inferred from the claim text.

Facts

Application

08/807,861Filed 26 Feb 1997 · continuation in part

Priority

23 Aug 1994

Granted

29 Dec 1998

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07K 14/5759
Hormones: products of obesity genes, e.g. leptin, obese , tub, fat
C07K 14/4702
Not used: regulators; Modulating activity
A01K 2217/05
Genetically modified animals: animals comprising random inserted nucleic acids
A61K 38/00
Medicinal preparations containing peptides

Family

Serial294,522Parent of this continuation-in-part · filed 23 Aug 1994

Serial470,868Parent of this continuation-in-part · filed 6 Jun 1995

Serial518,878Parent of this continuation-in-part · filed 23 Aug 1995

US 5,702,902 AParent of this continuation-in-part · filed 30 Dec 1997

US 5,741,666 AParent of this continuation-in-part · filed 21 Apr 1998

US 5,853,975 AThis patent

From the US filing history. Foreign family members aren’t listed.

Methods for identifying compositions for the treatment of body weight disorders, including obesity

Life of this patent

Methods for identifying compositions for the treatment of body weight disorders, including obesity

Life of this patent

Abstract

Claims7