Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissue and controlling their release
AssigneesSouthern Research Institute, The UAB Research Foundation
InventorsThomas R. Tice, Richard M. Gilley, John H. Eldridge, Jay K. Staas
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Abstract
A method, and compositions for use therein capable, of delivering a bioactive agent to an animal entailing the steps of encapsulating effective amounts of the agent in a biocompatible excipient to form microcapsules having a size less than approximately ten micrometers and administering effective amounts of the microcapsules to the animal. A pulsatile response is obtained, as well as mucosal and systemic immunity.
Claims52
A method of delivering a bioactive agent to the mucosally associated lymphoreticular tissues of an animal, comprising administering microcapsules to said animal so that an immunogenically effective amount of said microcapsules reach and are selectively taken up by said mucosally associated lymphoreticular tissues, wherein said microcapsules comprise said agent encapsulated in a biocompatible excipient and wherein said microcapsules are of a size of between approximately 1 micrometer and approximately 10 micrometers.
A method of delivering a bioactive agent to the mucosally associated lymphoreticular tissues of an animal, comprising administering microcapsules to said animal so that an immunogenically effective amount of said microcapsules reach and are selectively taken up by said mucosally associated lymphoreticular tissues, wherein said microcapsules comprise said agent encapsulated in a biocompatible excipient and wherein said microcapsules are of a size of less than approximately 10 micrometers.
A method of providing systemic immunity in an animal, comprising administering microcapsules to said animal so that immunogenically effective amount of said microcapsules reach and are selectively taken up by the mucosally-associated lymphoreticular tissues to provide a systemic immune response in said animal, wherein said microcapsules comprise a bioactive agent encapsulated in a biocompatible excipient and wherein said microcapsules are of a size of between approximately 1 micrometer and approximately 5 micrometers.
A method of providing mucosal immunity in an animal, comprising administering microcapsules to said animal so that an immunogenically effective amount of said microcapsules reach and are selectively taken up by the mucosally-associated lymphoreticular tissues to provide a mucosal immune response in said animal, wherein said microcapsules comprise a bioactive agent encapsulated in a biocompatible excipient and wherein said microcapsules are of a size of between approximately 5 micrometers and approximately 10 micrometers.
A method of providing mucosal immunity in an animal, comprising administering effective amounts of microcapsules to said animal so that an immunogenically effective amount of said microcapsules reach and are selectively taken up by the mucosally-associated lymphoreticular tissues to provide a mucosal immune response in said animal, wherein said microcapsules comprise effective amounts of a bioactive agent encapsulated in a biocompatible excipient and wherein said microcapsules are of a size of between approximately 1 micrometer and approximately 5 micrometers.
Dependencies are inferred from the claim text.