Delivery of controlled-release system(s)
AssigneeFuisz Technologies Ltd.
InventorsGarry L. Myers, Gerald E. Battist, Richard C. Fuisz
Life of this patent
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Abstract
The present invention is a method and a dosage unit for delivery of a controlled-release system. The dosage unit is a quick dissolve unit which can be prepared by mixing uncured shearform matrix and a controlled-release system, either molding or compacting a unit dosage form and curing the shearform matrix. The controlled-release systems used in the present invention include instantaneous release components, delayed release components, sustained release components, and combinations thereof.
Claims17
A comestible unit, having a controlled-release system, which disperses quickly in the mouth prepared from the process comprising:
- a) initiating crystallization of shearform matrix;
- b) before or after initiating crystallization combining a controlled-release system with said shearform matrix to form flowable, compactible micro-particulates;
- and
- c) compacting the combination resulting from step "b," which includes at least partially crystallized shearform matrix, to form said unit.
A method of administering a controlled-release system to a human host comprising:
- ingesting a quick dissolve comestible unit prepared by the method comprising;
- i) initiating crystallization of shearform matrix,
- ii) before or after initiating crystallization combining a controlled-release system with said shearform matrix to form flowable, compactible micro-particulates, and
- iii) compacting the combination resulting from step "ii," which includes at least particularly crystallized shearform matrix;
- retaining said unit in the oral cavity for a time sufficient to contact said unit with water introduced to said oral cavity;
- and
- introducing water to said oral cavity while said unit is retained therein whereby dispersion of said unit is significantly expedited.
Dependencies are inferred from the claim text.