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US 5,853,759 AGranted
Effervescent alendronate formulation
AssigneeMerck & Co., Inc.
InventorsAshok V. Katdare, Kenneth A. Kramer, Colin R. Gardner
Life of this patent
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Abstract
An effervescent formulation of alendronate contains an acid source, a carbonate source, a binder, a lubricant and optionally, flavoring agents, colorants and sweeteners.
Claims5
A formulation comprising (in mg):
- ______________________________________ Alendronate sodium 5-10 mg (in mg alendronic acid) citric acid 600-750 sodium bicarbonate 300-500 sodium carbonate 20-60 sodium benzoate 5-15 water 0-5. ______________________________________
A formulation comprising (in mg):
- ______________________________________ Alendronate sodium 5-10 (in mg alendronic acid) citric acid 450-650 sodium bicarbonate (total) 800-1150. ______________________________________
A formulation comprising (in mg):
- ______________________________________ Alendronate sodium 2.5-10 (in mg alendronic acid) citric acid 400-800 sodium bicarbonate 1000-2000 sodium carbonate 20-80 sodium benzoate 25-175 xylitol 100-300. ______________________________________
A formulation made by the process of combining:
- ______________________________________ Alendronate sodium 2.5-10 (in mg alendronic acid) citric acid 400-800 sodium bicarbonate 1000-2000 sodium carbonate 20-80 sodium benzoate 25-175 xylitol 100-300. ______________________________________
Dependencies are inferred from the claim text.