Methods of preparing gas and gaseous precursor-filled microspheres
AssigneeImaRx Pharmaceutical Corp.
InventorsEvan C. Unger, Thomas A. Fritz, Terry Matsunaga, VaradaRajan Ramaswami, David Yellowhair, Guanli Wu
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Abstract
Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.
Claims51
A method for preparing temperature activated gaseous precursor-filled lipid microspheres comprising shaking an aqueous solution comprising a lipid in the presence of a gaseous precursor at a temperature below the gel state to liquid crystalline state phase transition temperature of the lipid, wherein upon activation of said gaseous precursor to a gas the lipid microspheres have at least about 50% volume of gas in the interior thereof.
Dependencies are inferred from the claim text.