Cosmetic compositions containing lactate dehydrogenase inhibitors
AssigneeChesebrough-Pond's USA Co., Division of Conopco, Inc.
InventorsJohn Brian Bartolone, Christine Marie Penksa, Uma Santhanam, Brian David Lang
Life of this patent
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Abstract
Inhibitors of lactate dehydrogenase stimulate keratinocyte proliferation and collagen synthesis in cutaneous tissues. The inhibitors are used preferably with certain co-active ingredients such as pyruvic acid, acetic acid, acetoacetic acid, .beta.-hydroxybutyric acid, a Krebs cycle pathway metabolite, an aliphatic saturated or an unsaturated fatty acid containing from 8 to 26 carbon atoms, an .omega.-hydroxy acid containing from 22 to 34 carbon atoms, glutamic acid, glutamine, valine, alanine, leucine, and mixtures thereof.
Claims16
A composition for topical application to human skin, the composition comprising:
- (i) from about 0.001% to about 20% of an inhibitor of lactate dehydrogenase selected from the group consisting of oxamic acid, an N-substituted oxamic acid, 1,6-dihydro NAD, 4-pyridyl pyruvic acid, quinoline-2-carboxylic acid, suramin sodium, isoquinoline, papaverine, berberine, and mixtures thereof;
- (ii) a sunscreen;
- and
- (iii) a cosmetically acceptable vehicle for the lactate dehydrogenase inhibitor;
- and wherein the vehicle comprises water and wherein the lactate dehydrogenase inhibitor acts within the human skin.
A composition for topical application to human skin, the composition comprising:
- (i) from about 0.001% to about 20% of an inhibitor of lactate dehydrogenase selected from the group consisting of .beta.-chlorolactic acid and thiolactic acid, and mixtures thereof;
- and
- (ii) a cosmetically acceptable vehicle for the lactate dehydrogenase inhibitor, wherein the lactate dehydrogenase inhibitor acts within the human skin.
A method of improving the appearance of wrinkled, flaky, aged, photodamaged skin, the appearance of age spots which comprises applying topically thereto the composition comprising:
- (i) from about 0.001% to about 20% of an inhibitor of lactate dehydrogenase selected from the group consisting of oxamic acid, an N-substituted oxamic acid, .beta.-chlorolactic acid, thiolactic acid, 1,6-dihydro NAD, 4-pyridyl pyruvic acid, quinoline-2-carboxylicacid, suramin sodium, isoquinoline, papaverine, berberine, and mixtures thereof;
- (ii) a cosmetically acceptable vehicle for the lactate dehydrogenase inhibitor.
Dependencies are inferred from the claim text.