Delivery system for pharmaceutical agents encapsulated with oils
AssigneeAbbott Laboratories
InventorsMou-Ying Fu Lu, Akwete L. Adjei, Hillard W. Johnson
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Abstract
The present invention provides a uniform dispersion in aqueous medium of droplets comprising: (a) a core comprising water, a non-toxic C.sub.2 -C.sub.5 alkanol, a water-soluble drug, and a surfactant, and (b) a coating surrounding the core comprising one or more pharmaceutically acceptable oils. The compositions of the present invention are particularly useful for the oral delivery of therapeutic agents because of their potential for taste masking, prolonged action, and protection of the drug against the external environment and enzyme entrapment.
Claims11
A uniform dispersion of droplets in aqueous medium, suitable for oral administration, the droplets comprising
- a core comprising between about 2% volume by volume to about 10% volume by volume water,
- between about 2% volume by volume to about 10% volume by volume of a non-toxic C.sub.2 -C.sub.5 alkanol,
- between about 1 mg/ml to 10 mg/ml of a water soluble drug selected from the group consisting of agonists and antagonists of luteinizing hormone releasing hormone (LHRH), inhibitors of renin, and modulators of anaphylatoxin biologic factors, and a pharmaceutically acceptable salt thereof;
- between about 10% volume by volume to about 50% volume by volume of a surfactant, and
- a coating surrounding the core comprising between about 20% volume by volume to about 50% volume by volume one or more pharmaceutically acceptable oils, based upon the volume of the droplet, wherein the total volume of the droplets comprises from about 10% to about 30% the total volume of the dispersion, said droplets having a mean particle size of less than one micron in diameter.
Dependencies are inferred from the claim text.