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AssigneesThe Brigham and Women's Hospital, Inc., University of California, Los Angeles, Colorado State University Research Foundation
InventorsRobert L. Modlin, Peter A. Sieling, Michael B. Brenner, Steven A. Porcelli, Patrick J. Brennan
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The present invention is based on the observation that CD1 functions to present foreign and autoimmune antigens to a select subpopulation of T-cells. Based on this observation, the present invention provides methods for detecting the presence of a CD1-presented antigen in a sample, methods for purifying CD1-presented antigens, vaccines containing CD1-presented antigens, methods of blocking CD1 antigen presentation, methods of identifying and/or isolating CD1 blocking agents, methods of inducing CD1 expression, and T-cell lines for use in the methods disclosed herein. The CD1-presented antigens of the invention, unlike MHC-presented antigens, are non-polypeptide hydrophobic antigens. In particular, a CD1-presented antigen isolated from several mycobacterial species is a lipoarabinomannan (LAM).
A method for inducing a CD1-restricted immune response, wherein the method comprises administration to the mammal of an effective immune-enhancing amount of an isolated CD1-presented lipoarabinomannan antigen which can induce the CD1-restricted immune response thereby enhancing the immunity of the mammal.
A method for inducing a CD1-restricted immune response, wherein the method comprises administering to the mammal an effective immune-enhancing amount of an isolated CD1-presented lipoarabinomannan antigen to induce the CD1-restricted immune response and one or more additional components of a vaccine formulation, thereby enhancing the immunity of a mammal.
A method of stimulating a CD1-restricted immune response in a mammal by administration of an isolated CD1-presented lipoarabinomannan antigen to stimulate the CD1-restricted immune response.
A method for inducing a CD1-restricted immune response, wherein the method comprises administration to the mammal of an effective immune-enhancing amount of an isolated CD1-presented lipoarabinomannan antigen or a structurally-related glycolipid antigen which can induce the CD1-restricted immune response thereby enhancing the immunity of a mammal.
A method for inducing a CD1-restricted immune response, wherein the method comprises administering to the mammal an effective immune-enhancing amount of an isolated CD1-presented lipoarabinomannan antigen or a structurally-related glycolipid antigen to induce the CD1-restricted immune response and one or more additional components of a vaccine formulation thereby enhancing the immunity of a mammal.
A method of stimulating a CD1-restricted immune response in a mammal by administration of a CD1-presented lipoarabinomannan antigen or a structrally-related glycolipid antigen to stimulate the CD1-restricted immune response.
A method for inducing a CD1-restricted immune response, wherein the method comprises administration to the mammal of an effective immune-enhancing amount of an isolated nonpeptide CD1-presented antigen which can induce the CD1-restricted immune response, wherein the CD1presented antigen comprises the lipid domain or fatty acid moieties of lipoarabinomannan, thereby enhancing the immunity of a mammal.
A method for inducing a CD1-restricted immune response, wherein the method comprises administering to the mammal an effective immune-enhancing amount of an isolated nonpeptide CD1-presented antigen to induce the CD1 -restricted immune response and one or more additional components of a vaccine formulation, wherein the CD 1-presented antigen comprises the lipid domain or fatty acid moieties of lipoarabinomannan, thereby enhancing the immunity of a mammal.
A method of stimulating a CD1-restricted immune response in a mammal by administration of an isolated nonpeptide CD1-presented antigen to stimulate the CD1-restricted immune response, wherein the CD1-presented antigen comprises the lipid doman or fatty acid moieties of lipoarabinomannan.
Dependencies are inferred from the claim text.